However, that weekend high comes with an even higher price. The intense euphoria will eventually wear off as we are done partying. This is when the comedown kicks in. The happy hormones are now depleted during comedown with the brain attempting to regulate itself by reducing the biosynthesis process of these hormones dramatically. Without these hormones, we would feel tired, depressed, and anxious – also known as the "comedown blue".
Biosynthesis of these "happy hormones" involves a series of complex biochemical processes, including synthesis and conversion between different chemicals called "precursors". Some of these precursors are basically essential amino acids that we can obtain from food or dietary supplements. By increasing the intake of these amino acids during the comedown might help us to replenish some of these "happy hormones", and hopefully making the comedown a bit easier.